王斯楠博士任生物医学工程学院常任轨助理教授 (Tenure-track Assistant Professor)、研究员、博导、独立课题组组长 (Principal Investigator, PI)、分子影像和治疗实验室(Molecular Imaging and Therapy – MIT lab)主任。王斯楠博士在中国科学院上海药物所和华东理工大学获得硕士、博士学位。之后在加州大学旧金山分校历任博士后、助理研究员、副研究员。

王斯楠博士有丰富的 PET 探针开发和核素治疗经验，致力于挖掘新靶点的医学影像潜能，将新药物开发为分子影像探针，研究涉及药物化学、生物评价、分子影像等领域。王斯楠博士已经在相关领域发表高水平论文20余篇，其中以第一作者或共同第一作者在 Clin. Cancer. Res、Cancer Res.、J. Am. Chem. Soc. 等杂志发表论文多篇。

• 肿瘤靶向药物研发

• 基于新靶点的 PET 探针开发与优化

• 靶向肿瘤的核素治疗试剂的开发

• 高效同位素标记方法的开发

• 硼中子捕获治疗 (BNCT) 药物的开发

《肿瘤影像与诊疗》

《生物医学材料》

Reviewer for journals:

• Molecular Pharmaceutics

• The Journal of Organic Chemistry

Member for associations or committees:

• Society of Nuclear Medicine and Molecular Imaging (SNMMI)

• American Chemical Society

在上科大完成的工作：

• Guanxiang Hao, Yirong Zhang, Linyuan Wang, Changxian Yuan, Zhangxiang Yin, Zekun Yang, Ruizhi Wang, Ting Yu, Kaiyan Lou, Sinan Wang. B₁₀H₁₂(MeCN)₂ as a versatile reducing agent and its application in preparing carborane derivatives.Org. Chem. Front.2026, 13, 3215-3220.

• Yirong Zhang, Chenyang Ma, Lili Wang, Yuan Li, Yuzhe Lin, Zekun Yang, Changxian Yuan, Guanxiang Hao, Linyuan Wang, Hongjing Li, Nan Sun, Zhangxiang Yin, Yong Nian,^*Sinan Wang^*. Synthesis of Carborane-Containing Flavone and Flavonol Analogues as ER Agonists and COX Inhibitors.J. Nat. Prod.2026, 89, 1189-1197.

• Chaofan Li, Chenyang Ma, Yuzhe Lin, Changxian Yuan, Guanxiang Hao, Zhiguang Zhang, Sinan Wang. Synthesis of Carboranyl Flurbiprofen and its Biological Evaluation – an Example of Carborane not as a Phenyl Ring Surrogate. ChemistrySelect, 2026, 11, e05652.

• Changxian Yuan, Chaofan Li, Chenyang Ma, Yuzhe Lin, Linyuan Wang, Guanxiang Hao, Yirong Zhang, Hongjing Li, Yuan Li, Yu Zhao, Nan Sun, Tiezheng Chen, Zhiguang Zhang, Dengfeng Cheng and Sinan Wang. Synthesis and Anti-Tumor Evaluation of Carboranyl BMS-202 Analogues—A Case of Carborane Not as Phenyl Ring Mimetic. Molecules2025, 30, 4789.

• Zhongye Huang, Taoyong Wang, Sinan Wang*,and KaKing Yan*. Solvent-Free Mechanochemistry Overcomes the Low Solubility of Inorganic Silver Fluorides in the Construction of C−F and S−F Bonds. Org. Lett.2025, 27, 13437−13442.

• Yirong Zhang^†, Chuwei Yu^†, Linyuan Wang, Lina Zhou, Chaofan Li, Changxian Yuan, Nan Sun, Guanxiang Hao, Chenyang Ma, Yuzhe Lin, Hongjing Li, Jiali Hong, Jinhua Zhao, Kaiyan Lou, Rui Zhang,* Chengying Xie,* and Sinan Wang*. Synthesis and Anticancer Activity Evaluation of Novel Carborane-Containing Isoflavonoid Analogues. ACS Omega. 2025, 10, 18720-18732.

• Chaofan, Li, Xinyi He, Changrui Wei, Changxian Yuan, Xiaoqin Shen, Zhiguang Zhang*, Bin Cui*, Sinan Wang*. Organocatalytic Enantioselective Nucleophilic Substitution of Furfurals with Alcohols via a Remote Chiral Control. J. Org. Chem. 2025, 90, 3301−3307.

• Chaofan Li^†, Yingshuang Zhang^†, Ziyin Zhang, Yirong Zhang, Yuxuan Song, Linyuan Wang, Changxian Yuan, Guanxiang Hao, Nan Sun, Hongjing Li, Zhiguang Zhang, Yundong He*, Sinan Wang*. Discovery and biological evaluation of carborane-containing derivatives as TEAD auto palmitoylation inhibitors. Bioorg. Med. Chem. Lett. 2025, 121, 130155.

加入上科大之前的代表性工作：

• Anju Wadhwa^†, Sinan Wang^†, Bonell Patiño-Escobar, …… Robert R Flavell. CD46-targeted Theranostics for Positron Emission Tomography and ²²⁵Ac-Radiopharmaceutical Therapy of Multiple Myeloma.Clin. Cancer Res.2024, 30, 1009-1021.

• Sinan Wang^†, Jun Li^†, Jun Hua^† …… Robert R. Flavell*, Jiang He*. Molecular imaging of prostate cancer targeting CD46 using immunoPET. Clin. Cancer Res. 2021, 5, 1305-1315.

• Sinan Wang, Xiangmin Li, Hongwei Liu, …… Hao Li, and Wei Wang. Organocatalytic enantioselective direct addition of aldehydes to 4-vinylpyridines and electron-deficient vinylarenes and their synthetic applications. J. Am. Chem. Soc., 2015, 137, 2303-2310.

分子影像和核素治疗实验室 (Molecular Imaging and Radionuclide Therapy Lab) 致力于开发新型 PET 分子探针和核素治疗药物，用于肿瘤等疾病的早期诊断、药物药效评价和更好的理解疾病机理。核医学是一门交叉学科，实验室需要药物化学、放射化学、生物医学工程等专业知识。实验室主要开展以下几个方向的研究：

• PET 探针开发

• 靶向肿瘤的核素治疗

• PET 影像在药物开发中的应用