Sinan Wang, PhD, joined the ShanghaiTech University in 2021 as a tenure-track Assistant Professor in the School of Biomedical Engineering. Dr. Wang obtained his PhD degree in East China University of Science and Technology. Dr. Wang completed his postdoc training in University of California, San Francisco and subsequently became an associate professional researcher.

Dr. Wang has worked in PET probe development and radionuclide therapy for many years. His research aims to explore the potential of novel biomarkers as a nuclear medicine target, and develop new drugs as molecular imaging probes. His lab needs different specialties in medicinal chemistry, biological evaluation and molecular imaging. Dr. Wang has published over 20 papers, including several first-author papers such as Clin. Cancer. Res and J. Am. Chem. Soc.  

• Development and optimization of PET probe targeting novel biomarkers

• Radionuclide therapy for cancer treatment

• Development of efficient radiolabeling methodology

• Development of boron neutron capture therapy (BNCT) reagents

Reviewer for journals:

• Molecular Pharmaceutics

• The Journal of Organic Chemistry

Member for associations or committees:

• Society of Nuclear Medicine and Molecular Imaging (SNMMI)

• American Chemical Society

Research at ShanghaiTech University

• Guanxiang Hao, Yirong Zhang, Linyuan Wang, Changxian Yuan, Zhangxiang Yin, Zekun Yang, Ruizhi Wang, Ting Yu, Kaiyan Lou, Sinan Wang. B₁₀H₁₂(MeCN)₂ as a versatile reducing agent and its application in preparing carborane derivatives.Org. Chem. Front.2026, 13, 3215-3220.

• Yirong Zhang, Chenyang Ma, Lili Wang, Yuan Li, Yuzhe Lin, Zekun Yang, Changxian Yuan, Guanxiang Hao, Linyuan Wang, Hongjing Li, Nan Sun, Zhangxiang Yin, Yong Nian,^*Sinan Wang^*. Synthesis of Carborane-Containing Flavone and Flavonol Analogues as ER Agonists and COX Inhibitors.J. Nat. Prod.2026, 89, 1189-1197.

• Chaofan Li, Chenyang Ma, Yuzhe Lin, Changxian Yuan, Guanxiang Hao, Zhiguang Zhang, Sinan Wang. Synthesis of Carboranyl Flurbiprofen and its Biological Evaluation – an Example of Carborane not as a Phenyl Ring Surrogate. ChemistrySelect, 2026, 11, e05652.

• Changxian Yuan, Chaofan Li, Chenyang Ma, Yuzhe Lin, Linyuan Wang, Guanxiang Hao, Yirong Zhang, Hongjing Li, Yuan Li, Yu Zhao, Nan Sun, Tiezheng Chen, Zhiguang Zhang, Dengfeng Cheng and Sinan Wang. Synthesis and Anti-Tumor Evaluation of Carboranyl BMS-202 Analogues—A Case of Carborane Not as Phenyl Ring Mimetic. Molecules2025, 30, 4789.

• Zhongye Huang, Taoyong Wang, Sinan Wang*,and KaKing Yan*. Solvent-Free Mechanochemistry Overcomes the Low Solubility of Inorganic Silver Fluorides in the Construction of C−F and S−F Bonds. Org. Lett.2025, 27, 13437−13442.

• Yirong Zhang^†, Chuwei Yu^†, Linyuan Wang, Lina Zhou, Chaofan Li, Changxian Yuan, Nan Sun, Guanxiang Hao, Chenyang Ma, Yuzhe Lin, Hongjing Li, Jiali Hong, Jinhua Zhao, Kaiyan Lou, Rui Zhang,* Chengying Xie,* and Sinan Wang*. Synthesis and Anticancer Activity Evaluation of Novel Carborane-Containing Isoflavonoid Analogues. ACS Omega. 2025, 10, 18720-18732.

• Chaofan, Li, Xinyi He, Changrui Wei, Changxian Yuan, Xiaoqin Shen, Zhiguang Zhang*, Bin Cui*, Sinan Wang*. Organocatalytic Enantioselective Nucleophilic Substitution of Furfurals with Alcohols via a Remote Chiral Control. J. Org. Chem. 2025, 90, 3301−3307.

• Chaofan Li^†, Yingshuang Zhang^†, Ziyin Zhang, Yirong Zhang, Yuxuan Song, Linyuan Wang, Changxian Yuan, Guanxiang Hao, Nan Sun, Hongjing Li, Zhiguang Zhang, Yundong He*, Sinan Wang*. Discovery and biological evaluation of carborane-containing derivatives as TEAD auto palmitoylation inhibitors. Bioorg. Med. Chem. Lett. 2025, 121, 130155.

Representative Research Before Joining ShanghaiTech

• Anju Wadhwa^†, Sinan Wang^†, Bonell Patiño-Escobar, …… Robert R Flavell. CD46-targeted Theranostics for Positron Emission Tomography and ²²⁵Ac-Radiopharmaceutical Therapy of Multiple Myeloma.Clin. Cancer Res.2024, 30, 1009-1021.

• Sinan Wang^†, Jun Li^†, Jun Hua^† …… Robert R. Flavell*, Jiang He*. Molecular imaging of prostate cancer targeting CD46 using immunoPET. Clin. Cancer Res. 2021, 5, 1305-1315.

• Sinan Wang, Xiangmin Li, Hongwei Liu, …… Hao Li, and Wei Wang. Organocatalytic enantioselective direct addition of aldehydes to 4-vinylpyridines and electron-deficient vinylarenes and their synthetic applications. J. Am. Chem. Soc., 2015, 137, 2303-2310.

The Molecular Imaging and Radionuclide Therapy Lab aims to develop novel PET imaging probes and radionuclide therapeutic reagents for early-stage tumor diagnosis, drug evaluation and better understanding of disease mechanism. Training opportunities in our lab are by nature interdisciplinary to meet the special challenge for nuclear medicine which requires specialties in medicinal chemistry, radiochemistry and biomedical engineering. Our lab focuses on the following research fields: 

• Development of novel PET probes

• Radionuclide therapy for cancer treatment

• Application of PET imaging in drug development